Protein Details: KCa3.1 (Potassium intermediate/small conductance calcium-activated channel; subfamily N; member 4)
Protein ID
ICDB_Pro_0285
Protein Name
KCa3.1 (Potassium intermediate/small conductance calcium-activated channel; subfamily N; member 4)
Gene Name
Kcnn4
Organism
Mus musculus (Mouse)
Length
425 amino acids
AlphaFoldDB
AF-O89109-F1-model_v4.pdb
Function
Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. Plays a role in the late stages of EGF-induced macropinocytosis (By similarity)
Sequence
MGGELVTGLGALRRRKRLLEQEKRVAGWALVLAGTGIGLMVLHAEMLWFLGCKWVLYLLLVKCLITLSTAFLLCLIVVFHAKEVQLFMTDNGLRDWRVALTRRQVAQILLELLVCGVHPVPLRSPHCALAGEATDAQPWPGFLGEGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYRSIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLTDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHNFMMDIHYAKEMKESAARLLQEAWMYYKHTRRKDSRAARRHQRKMLAAIHTFRQVRLKHRKLREQVNSMVDISKMHMILCDLQLGLSSSHRALEKRIDGLAGKLDALTELLGTALQQQQLPEPSQEAT
PDB Structures
Ligand Binding
Binding Site
Disease
Location
DOI ID
10.1074/jbc.273.34.21542; 10.1126/science.1112014; 10.1101/gr.2596504; 10.1074/jbc.m110.168070
RefSeq
NP_001156982.1; NP_032459.3; XP_006539626.1